The firm said it had been selected following an 18-month review process by Stanlib to select a partner for the global and EM equity element of its product offering.
Stanlib manages more than $44bn for retail and institutional clients and partners with offshore asset managers with the aim of delivering "consistent risk-adjusted returns across its offshore range".
According to Threadneedle, it had been selected "not only for its skill set and strong emerging and developed market equity performance", but also for its investment philosophy which is aligned with that of Stanlib.
Threadneedle uses a team-based approach, which it says can be thanked for its strong record of outperformance across asset classes.
It added that all of its global equity and emerging market equity portfolios had outperformed their benchmark or peer group over three and five years, as at 30 June 2012.
Campbell Fleming, Threadneedle’s head of global distribution, said: "This arrangement will allow investors based in Africa to access to Threadneedle’s investment expertise, and supports our ongoing international growth. We are excited to be working with Stanlib and look forward to further building on this relationship in the future."